Altered subthalamo-pallidal synchronisation in parkinsonian dyskinesias

The aim of this work was to study the role of subthalamo-pallidal synchronisation in the pathophysiology of dyskinesias. We recorded local field potentials (LFPs) in a patient with Parkinson’s disease and left surgery induced dyskinesias with double, bilateral deep brain stimulation electrode implan...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2005-03, Vol.76 (3), p.426-428
Hauptverfasser:	Foffani, G, Ardolino, G, Meda, B, Egidi, M, Rampini, P, Caputo, E, Baselli, G, Priori, A
Format:	Artikel
Sprache:	eng
Schlagworte:	basal ganglia Biological and medical sciences DBS Deep Brain Stimulation Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug toxicity and drugs side effects treatment Dyskinesias - etiology Dyskinesias - physiopathology Dyskinesias - therapy Electrodes Female globus pallidus Globus Pallidus - pathology Globus Pallidus - physiology globus pallidus internus GPi Humans Hypotheses LFPs local field potential local field potentials Medical sciences Middle Aged Neurology Parkinson's disease Parkinsonian Disorders - complications Parkinsonian Disorders - therapy Patients Pharmacology. Drug treatments Phenomenology Short Report STN subthalamic nucleus Subthalamic Nucleus - pathology Subthalamic Nucleus - physiology Surgery Toxicity: nervous system and muscle Unified Parkinson’s Disease Rating Scale UPDRS
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Zusammenfassung:	The aim of this work was to study the role of subthalamo-pallidal synchronisation in the pathophysiology of dyskinesias. We recorded local field potentials (LFPs) in a patient with Parkinson’s disease and left surgery induced dyskinesias with double, bilateral deep brain stimulation electrode implants in the subthalamic nucleus (STN) and the globus pallidus internus (GPi). Synchronisation was studied through coherence analysis. In the nuclei contralateral to the dyskinetic side of the body there was decreased STN-GPi coherence in the high beta range (20–30 Hz) and an enhanced coherence at low frequencies (
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp.2004.043547