Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer’s disease

Objectives: To determine in vivo cortical acetylcholinesterase (AChE) activity and cognitive effects in subjects with mild Alzheimer’s disease (AD, n = 14) prior to and after 12 weeks of donepezil therapy. Methods: Cognitive and N-[11C]methyl-piperidin-4-yl propionate ([11C]PMP) AChE positron emissi...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2005-03, Vol.76 (3), p.315-319
Hauptverfasser:	Bohnen, N I, Kaufer, D I, Hendrickson, R, Ivanco, L S, Lopresti, B J, Koeppe, R A, Meltzer, C C, Constantine, G, Davis, J G, Mathis, C A, DeKosky, S T, Moore, R Y
Format:	Artikel
Sprache:	eng
Schlagworte:	[11C]PMP acetylcholinesterase Acetylcholinesterase - drug effects Acetylcholinesterase - pharmacology AChE Aged Aged, 80 and over AIR Alzheimer Disease - complications Alzheimer Disease - drug therapy Alzheimer's disease Attention - drug effects automated image registration California Verbal Learning Test Cerebral Cortex - enzymology ChE-I cholinesterase inhibitor Cholinesterase Inhibitors - pharmacology Cognition Disorders - drug therapy Cognition Disorders - etiology Controlled Oral Word Association COWA CVLT Dementia donepezil Enzymes Female Humans Indans - pharmacology long term memory LTM magnetic resonance Male Memory N-[11C]methyl-piperidin-4-yl propionate Neuropsychology PET Piperidines - pharmacology Positron-Emission Tomography region of interest Registration ROI Scanners short term memory SPGR spoiled gradient recall STM TMT Trail Making Test
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Zusammenfassung:	Objectives: To determine in vivo cortical acetylcholinesterase (AChE) activity and cognitive effects in subjects with mild Alzheimer’s disease (AD, n = 14) prior to and after 12 weeks of donepezil therapy. Methods: Cognitive and N-[11C]methyl-piperidin-4-yl propionate ([11C]PMP) AChE positron emission tomography (PET) assessments before and after donepezil therapy. Results: Analysis of the PET data revealed mean (temporal, parietal, and frontal) cortical donepezil induced AChE inhibition of 19.1% (SD 9.4%) (t = −7.9; p
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp.2004.038729