Metabolic interaction between ApoE genotype and onset age in Alzheimer’s disease: implications for brain reserve

Background: Clinically apparent Alzheimer’s disease (AD) is thought to result when brain tissue damage exceeds a critical threshold of “brain reserve”, a process possibly accelerated by the apolipoprotein E (ApoE) E4 allele. The interaction between onset age and ApoE genotype was investigated to ass...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2005-01, Vol.76 (1), p.15-23
Hauptverfasser:	Mosconi, L, Herholz, K, Prohovnik, I, Nacmias, B, De Cristofaro, M T R, Fayyaz, M, Bracco, L, Sorbi, S, Pupi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Activities of daily living Age Age of Onset Aged Aged, 80 and over Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease ApoE apolipoprotein E Apolipoproteins E - genetics basal frontal cortex BFC Biological and medical sciences Brain - diagnostic imaging Brain - metabolism brain reserve brain reserve capacity BRC Case-Control Studies CDR Clinical Dementia Rating Cognitive ability computed tomography controls Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia early onset early onset AD EOAD FDG-PET Female field of view Fluorodeoxyglucose F18 - pharmacokinetics fluorodeoxyglucose positron emission tomography FOV General Linear Model Genotype Genotype & phenotype GLM Glucose Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans IADL Inventory of Activities of Daily Living late onset AD LOAD magnetic resonance imaging Male medial temporal lobe Medical sciences Metabolism Middle Aged Mini-Mental State Examination MMSE MRI MTL Nervous system (semeiology, syndromes) NEST-DD Network for Efficiency and Standardization of Dementia Diagnosis neuritic plaques neurofibrillary tangles Neurology Neuropsychology NFT Positron-Emission Tomography Radiopharmaceuticals - pharmacokinetics SPM statistical parametric map Tomography
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Zusammenfassung:	Background: Clinically apparent Alzheimer’s disease (AD) is thought to result when brain tissue damage exceeds a critical threshold of “brain reserve”, a process possibly accelerated by the apolipoprotein E (ApoE) E4 allele. The interaction between onset age and ApoE genotype was investigated to assess whether early disease onset (
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp.2003.030882