Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer’s disease
Objectives: Declines in brain glucose metabolism have been described early in Alzheimer’s disease (AD), and there is evidence that a genetic predisposition to AD contributes to accelerate this process. The epsilon4 (e4) allele of the apolipoprotein E (ApoE) gene has been implicated as a major risk f...
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Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2004-03, Vol.75 (3), p.370-376 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Objectives: Declines in brain glucose metabolism have been described early in Alzheimer’s disease (AD), and there is evidence that a genetic predisposition to AD contributes to accelerate this process. The epsilon4 (e4) allele of the apolipoprotein E (ApoE) gene has been implicated as a major risk factor in this process. The aim of this FDG-PET study was to assess the ApoE e4 dose related effect on regional cerebral glucose metabolism (METglc) in clinical AD patients, with statistical voxel based methods. Methods: Eighty six consecutive mild to moderate AD patients included in the Network for Efficiency and Standardisation of Dementia Diagnosis database underwent FDG-PET scans at rest. PCR was used to determine the ApoE genotype. Patients were grouped as e4 non-carriers (n = 46), e3/e4 (n = 27) and e4/e4 (n = 13) carriers. A voxel-based mapping program was used to compare each AD subgroup with a database of 35 sex and age matched controls (p |
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ISSN: | 0022-3050 1468-330X |
DOI: | 10.1136/jnnp.2003.014993 |