Relation of type 2 diabetes to individual admixture and candidate gene polymorphisms in the Hispanic American population of San Luis Valley, Colorado
The prevalence of type 2 diabetes is higher in populations of Native American ancestry, and in Hispanic American populations formed by admixture between Europeans and Native Americans, than in populations of European ancestry. 1 One approach to distinguishing between environmental and genetic explan...
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| Veröffentlicht in: | Journal of medical genetics 2004-11, Vol.41 (11), p.e116-e116 |
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| container_title | Journal of medical genetics |
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| creator | Parra, E J Hoggart, C J Bonilla, C Dios, S Norris, J M Marshall, J A Hamman, R F Ferrell, R E McKeigue, P M Shriver, M D |
| description | The prevalence of type 2 diabetes is higher in populations of Native American ancestry, and in Hispanic American populations formed by admixture between Europeans and Native Americans, than in populations of European ancestry. 1 One approach to distinguishing between environmental and genetic explanations for this difference is to study the relationship of type 2 diabetes risk to individual admixture proportions (the proportions of an individual's genome that are of European and Native American ancestry). [...]our study would have detected effects of the magnitude described in the Mexican American sample in which the original association of CAPN10 and type 2 diabetes was reported (OR>2). |
| doi_str_mv | 10.1136/jmg.2004.018887 |
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[...]our study would have detected effects of the magnitude described in the Mexican American sample in which the original association of CAPN10 and type 2 diabetes was reported (OR>2).</description><identifier>ISSN: 0022-2593</identifier><identifier>ISSN: 1468-6244</identifier><identifier>EISSN: 1468-6244</identifier><identifier>DOI: 10.1136/jmg.2004.018887</identifier><identifier>PMID: 15520398</identifier><identifier>CODEN: JMDGAE</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>admixture ; Adult ; Aged ; AIMs ; ancestry informative markers ; candidate genes ; Colorado ; Cultural differences ; Diabetes ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes Mellitus, Type 2 - genetics ; Electronic Letter ; Fasting ; Female ; Gene Frequency ; Genealogy ; Genes ; Genetic Predisposition to Disease ; Genetics, Population ; Haplotypes ; Hispanic Americans ; Hispanic Americans - genetics ; Humans ; Insulin ; Insulin resistance ; Linkage Disequilibrium ; Male ; Markov chain Monte Carlo simulation ; MCMC simulation ; Middle Aged ; Native North Americans ; Polymorphism, Single Nucleotide ; Population ; Proteins ; San Luis Valley Diabetes Study ; SLVDS ; Studies ; type 2 diabetes</subject><ispartof>Journal of medical genetics, 2004-11, Vol.41 (11), p.e116-e116</ispartof><rights>Copyright 2004 Journal of Medical Genetics</rights><rights>Copyright: 2004 Copyright 2004 Journal of Medical Genetics</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b492t-ef4dde718a1f365880bf53ad57e2db7f378986bd176b967594db3e4baec4dce13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1735625/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1735625/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15520398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parra, E J</creatorcontrib><creatorcontrib>Hoggart, C J</creatorcontrib><creatorcontrib>Bonilla, C</creatorcontrib><creatorcontrib>Dios, S</creatorcontrib><creatorcontrib>Norris, J M</creatorcontrib><creatorcontrib>Marshall, J A</creatorcontrib><creatorcontrib>Hamman, R F</creatorcontrib><creatorcontrib>Ferrell, R E</creatorcontrib><creatorcontrib>McKeigue, P M</creatorcontrib><creatorcontrib>Shriver, M D</creatorcontrib><title>Relation of type 2 diabetes to individual admixture and candidate gene polymorphisms in the Hispanic American population of San Luis Valley, Colorado</title><title>Journal of medical genetics</title><addtitle>J Med Genet</addtitle><description>The prevalence of type 2 diabetes is higher in populations of Native American ancestry, and in Hispanic American populations formed by admixture between Europeans and Native Americans, than in populations of European ancestry. 1 One approach to distinguishing between environmental and genetic explanations for this difference is to study the relationship of type 2 diabetes risk to individual admixture proportions (the proportions of an individual's genome that are of European and Native American ancestry). [...]our study would have detected effects of the magnitude described in the Mexican American sample in which the original association of CAPN10 and type 2 diabetes was reported (OR>2).</description><subject>admixture</subject><subject>Adult</subject><subject>Aged</subject><subject>AIMs</subject><subject>ancestry informative markers</subject><subject>candidate genes</subject><subject>Colorado</subject><subject>Cultural differences</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - ethnology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Electronic Letter</subject><subject>Fasting</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genealogy</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics, Population</subject><subject>Haplotypes</subject><subject>Hispanic Americans</subject><subject>Hispanic Americans - genetics</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Markov chain Monte Carlo simulation</subject><subject>MCMC simulation</subject><subject>Middle Aged</subject><subject>Native North Americans</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Proteins</subject><subject>San Luis Valley Diabetes Study</subject><subject>SLVDS</subject><subject>Studies</subject><subject>type 2 diabetes</subject><issn>0022-2593</issn><issn>1468-6244</issn><issn>1468-6244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU9v1DAQxSNERZfCmRuyhMQBka0dx7FzQSor-kdaAaKwHC07nux6SeJgO1X3g_B9cbWrFrhwsaWZ33szo5dlLwieE0Kr022_nhcYl3NMhBD8UTYjZSXyqijLx9kM46LIC1bT4-xpCFuMCeWkepIdE8YKTGsxy359gU5F6wbkWhR3I6ACGas0RAgoOmQHY2-smVSHlOntbZw8IDUY1KTHGhUBrWEANLpu1zs_bmzoQ1KhuAF0acOoBtugsx68TYqEjdPDvOtUWU42oJXqOti9RQvXOa-Me5YdtaoL8Pzwn2Tfzj98XVzmy08XV4uzZa7Luog5tKUxwIlQpKUVEwLrllFlGIfCaN5SLmpRaUN4peuKs7o0mkKpFTSlaYDQk-zd3necdA-pNESvOjl62yu_k05Z-XdnsBu5djeScMqqgiWD1wcD735OEKLsbWig69QAbgqy4pgSjnkCX_0Dbt3kh3Rc8hKEMFHXNFGne6rxLgQP7f0qBMu7wGUKXN4FLveBJ8XLPy944A8JJyDfAzZEuL3vK_8jLUc5kx9XC1muPl-__36xlOeJf7Pndb_97_Tf3enG4w</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>Parra, E J</creator><creator>Hoggart, C J</creator><creator>Bonilla, C</creator><creator>Dios, S</creator><creator>Norris, J M</creator><creator>Marshall, J A</creator><creator>Hamman, R F</creator><creator>Ferrell, R E</creator><creator>McKeigue, P M</creator><creator>Shriver, M D</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20041101</creationdate><title>Relation of type 2 diabetes to individual admixture and candidate gene polymorphisms in the Hispanic American population of San Luis Valley, Colorado</title><author>Parra, E J ; Hoggart, C J ; Bonilla, C ; Dios, S ; Norris, J M ; Marshall, J A ; Hamman, R F ; Ferrell, R E ; McKeigue, P M ; Shriver, M D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b492t-ef4dde718a1f365880bf53ad57e2db7f378986bd176b967594db3e4baec4dce13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>admixture</topic><topic>Adult</topic><topic>Aged</topic><topic>AIMs</topic><topic>ancestry informative markers</topic><topic>candidate genes</topic><topic>Colorado</topic><topic>Cultural differences</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - ethnology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Electronic Letter</topic><topic>Fasting</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genealogy</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics, Population</topic><topic>Haplotypes</topic><topic>Hispanic Americans</topic><topic>Hispanic Americans - genetics</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Markov chain Monte Carlo simulation</topic><topic>MCMC simulation</topic><topic>Middle Aged</topic><topic>Native North Americans</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Proteins</topic><topic>San Luis Valley Diabetes Study</topic><topic>SLVDS</topic><topic>Studies</topic><topic>type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parra, E J</creatorcontrib><creatorcontrib>Hoggart, C J</creatorcontrib><creatorcontrib>Bonilla, C</creatorcontrib><creatorcontrib>Dios, S</creatorcontrib><creatorcontrib>Norris, J M</creatorcontrib><creatorcontrib>Marshall, J A</creatorcontrib><creatorcontrib>Hamman, R F</creatorcontrib><creatorcontrib>Ferrell, R E</creatorcontrib><creatorcontrib>McKeigue, P M</creatorcontrib><creatorcontrib>Shriver, M D</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parra, E J</au><au>Hoggart, C J</au><au>Bonilla, C</au><au>Dios, S</au><au>Norris, J M</au><au>Marshall, J A</au><au>Hamman, R F</au><au>Ferrell, R E</au><au>McKeigue, P M</au><au>Shriver, M D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of type 2 diabetes to individual admixture and candidate gene polymorphisms in the Hispanic American population of San Luis Valley, Colorado</atitle><jtitle>Journal of medical genetics</jtitle><addtitle>J Med Genet</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>41</volume><issue>11</issue><spage>e116</spage><epage>e116</epage><pages>e116-e116</pages><issn>0022-2593</issn><issn>1468-6244</issn><eissn>1468-6244</eissn><coden>JMDGAE</coden><abstract>The prevalence of type 2 diabetes is higher in populations of Native American ancestry, and in Hispanic American populations formed by admixture between Europeans and Native Americans, than in populations of European ancestry. 1 One approach to distinguishing between environmental and genetic explanations for this difference is to study the relationship of type 2 diabetes risk to individual admixture proportions (the proportions of an individual's genome that are of European and Native American ancestry). [...]our study would have detected effects of the magnitude described in the Mexican American sample in which the original association of CAPN10 and type 2 diabetes was reported (OR>2).</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>15520398</pmid><doi>10.1136/jmg.2004.018887</doi><oa>free_for_read</oa></addata></record> |
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| subjects | admixture Adult Aged AIMs ancestry informative markers candidate genes Colorado Cultural differences Diabetes Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Electronic Letter Fasting Female Gene Frequency Genealogy Genes Genetic Predisposition to Disease Genetics, Population Haplotypes Hispanic Americans Hispanic Americans - genetics Humans Insulin Insulin resistance Linkage Disequilibrium Male Markov chain Monte Carlo simulation MCMC simulation Middle Aged Native North Americans Polymorphism, Single Nucleotide Population Proteins San Luis Valley Diabetes Study SLVDS Studies type 2 diabetes |
| title | Relation of type 2 diabetes to individual admixture and candidate gene polymorphisms in the Hispanic American population of San Luis Valley, Colorado |
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