Relation of type 2 diabetes to individual admixture and candidate gene polymorphisms in the Hispanic American population of San Luis Valley, Colorado

The prevalence of type 2 diabetes is higher in populations of Native American ancestry, and in Hispanic American populations formed by admixture between Europeans and Native Americans, than in populations of European ancestry. 1 One approach to distinguishing between environmental and genetic explanations for this difference is to study the relationship of type 2 diabetes risk to individual admixture proportions (the proportions of an individual's genome that are of European and Native American ancestry). [...]our study would have detected effects of the magnitude described in the Mexican American sample in which the original association of CAPN10 and type 2 diabetes was reported (OR>2).