A common ancestor for COCH related cochleovestibular (DFNA9) patients in Belgium and The Netherlands bearing the P51S mutation

[...]it is commonly known that many hearing impaired people also suffer from balance problems. [...]it is now recognised that many syndromes with genetic hearing impairment also show a dysfunction of the vestibular system. 3 The prevalence of vestibular dysfunction may be severely underestimated, as...

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Veröffentlicht in:Journal of medical genetics 2001-01, Vol.38 (1), p.61-64
Hauptverfasser: FRANSEN, ERIK, VERSTREKEN, MARGRIET, BOM, STEVEN J H, LEMAIRE, FRANÇOIS, KEMPERMAN, MARTIJN H, DE KOK, YVETTE J M, WUYTS, FLORIS L, VERHAGEN, WIM I M, HUYGEN, PATRICK L M, MCGUIRT, WYMAN T, SMITH, RICHARD J H, VAN MALDERGEM, LIONEL, DECLAU, FRANK, CREMERS, COR W R J, VAN DE HEYNING, PAUL H, CREMERS, FRANS P M, VAN CAMP, GUY
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Sprache:eng
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Zusammenfassung:[...]it is commonly known that many hearing impaired people also suffer from balance problems. [...]it is now recognised that many syndromes with genetic hearing impairment also show a dysfunction of the vestibular system. 3 The prevalence of vestibular dysfunction may be severely underestimated, as it often remains unnoticed until specialised vestibular tests are performed. [...]the data obtained here indicate that the Généthon genetic map around the COCHlocus is not reliable. [...]the intermarker distances around theCOCH gene are unknown and even a rough estimate of the age of the mutation is not feasible.
ISSN:0022-2593
1468-6244
DOI:10.1136/jmg.38.1.61