The winding road towards evidence based diagnoses

The results of these analyses may imply, for example, that a test is recommended in the diagnosis of a certain target disease in specific strata of age or gender; or, conversely, that its application is unwarranted in the presence of specific comorbidity. [...]the use of complex analytical methods does not necessarily entail that the implications of the research findings are difficult to turn into practical recommendations. [...]the need for clinical trials should be carefully assessed.