Increased serum concentrations of advanced glycation end products: a marker of coronary artery disease activity in type 2 diabetic patients

OBJECTIVE To assess whether the concentrations of serum advanced glycation end products (AGE) in diabetic patients with obstructive coronary artery disease differ from those in type 2 diabetic patients without obstructive coronary artery disease. DESIGN Serum AGE concentrations were measured in type...

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Veröffentlicht in:	British heart journal 2001-01, Vol.85 (1), p.87-91
Hauptverfasser:	Kiuchi, K, Nejima, J, Takano, T, Ohta, M, Hashimoto, H
Format:	Artikel
Sprache:	eng
Schlagworte:	advanced glycation end products Age Aged Associated diseases and complications Atherosclerosis Basic Research Biological and medical sciences Biomarkers - blood Blood pressure Cardiovascular disease Cholesterol Complications and side effects Coronary Angiography coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - etiology Coronary heart disease Coronary vessels Cytokines Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Glucose Glycated Hemoglobin A Glycation End Products, Advanced - blood Health aspects Heart attacks Humans Hyperglycemia Hypertension Male Medical imaging Medical sciences Middle Aged non-insulin dependent diabetes Pathogenesis Physiological aspects Proteins Rodents Type 2 diabetes
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Zusammenfassung:	OBJECTIVE To assess whether the concentrations of serum advanced glycation end products (AGE) in diabetic patients with obstructive coronary artery disease differ from those in type 2 diabetic patients without obstructive coronary artery disease. DESIGN Serum AGE concentrations were measured in type 2 diabetic patients and in non-diabetic patients, both with and without obstructive coronary artery disease, and the relation between these values and coronary disease severity was evaluated. RESULTS Mean (SD) serum AGE concentrations were higher (p
ISSN:	1355-6037 0007-0769 1468-201X
DOI:	10.1136/heart.85.1.87