Antiarrhythmics—from cell to clinic: past, present, and future

[...]we may be on the verge of an era where arrhythmia management will no longer be dominated by trial and error based observational treatment. [...]we shall initially consider the electrophysiological characteristics of cardiac action potentials, aspects of ion channel function, and ion channels as...

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Veröffentlicht in:	British heart journal 2000-07, Vol.84 (1), p.14-24
Hauptverfasser:	Hancox, J C, Patel, K C R, Jones, J V
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Anti-Arrhythmia Agents - classification Anti-Arrhythmia Agents - pharmacology Anti-Arrhythmia Agents - therapeutic use Antiarrhythmics Antiarythmic agents Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - physiopathology Biological and medical sciences Cardiac arrhythmia Cardiovascular system Gene Expression Humans Ion Channel Gating - drug effects Ion Channels - drug effects Ion Channels - genetics Ion Transport - drug effects Ions Medical sciences Membrane Potentials - drug effects Membrane Potentials - physiology Pharmacology. Drug treatments Potassium Review Scholarships & fellowships Sodium
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Beschreibung
Zusammenfassung:	[...]we may be on the verge of an era where arrhythmia management will no longer be dominated by trial and error based observational treatment. [...]we shall initially consider the electrophysiological characteristics of cardiac action potentials, aspects of ion channel function, and ion channels as sites of antiarrhythmic drug action.
ISSN:	1355-6037 0007-0769 1468-201X
DOI:	10.1136/heart.84.1.14