Function of immunoglobulin A in immunity

Mouse IgA does not bind to human FcÎ±R. In this publication, the Dutch group show that in the transgenic mouse model, human FcÎ±R is expressed not only on circulating leucocytes but also on liver Kupffer cells. Secretory IgA did not initiate phagocytosis. [...]interactions between serum IgA and FcÎ±...

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Veröffentlicht in:	Gut 2000-12, Vol.47 (6), p.751-752
1. Verfasser:	KERR, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, immunoglobulins Antigens, CD - metabolism Bacteria Biological and medical sciences Colon Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunity, Mucosal - immunology Immunoglobulin A - physiology Immunoglobulins Kupffer Cells - physiology Liver Liver diseases Lymphocytes Mice Mice, Transgenic Molecular immunology Neutrophils Phagocytosis Receptors, Fc - metabolism Rodents Science Alert Structure Transgenic animals
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Beschreibung
Zusammenfassung:	Mouse IgA does not bind to human FcÎ±R. In this publication, the Dutch group show that in the transgenic mouse model, human FcÎ±R is expressed not only on circulating leucocytes but also on liver Kupffer cells. Secretory IgA did not initiate phagocytosis. [...]interactions between serum IgA and FcÎ±RI on Kupffer cells may provide a 'second line of defense' in mucosal immunity, by eliminating invasive bacteria entering through the portal circulation and thus preventing disease.
ISSN:	0017-5749 1468-3288 1458-3288
DOI:	10.1136/gut.47.6.751