Timing of aspirin administration in acute myocardial infarction

PRCT Overall vascular mortality 4% relative risk reduction (0-4 h v 5-12 h v 13-24 h, p=NS) Not the primary aim of the study, so very hard to extract data. iv streptokinase or aspirin or both or neither Odds of death at 5 weeks v placebo Subgroup analysis mortality v time of aspirin administration from onset of symptoms at 0-4 h, 5-12 h, 5-24 h 0-4 h 0.75 (SD=0.07) 5-12 h 0.79 (SD=0.07) 13-24 h 0.79 (SD=0.12) Comments While this paper does not reach statistical significance it does show a trend in reduction of mortality with early aspirin administration.