Effects of latanoprost and dipivefrin, alone or combined, on intraocular pressure and on blood-aqueous barrier permeability

AIM To investigate the effect on intraocular pressure (IOP) and aqueous flare of topical applications of latanoprost and dipivefrin alone or combined. METHODS 22 patients with open angle glaucoma or ocular hypertension were included in a 4 week open label study. Median age was 68 years (range 50–79). They were allocated to either 2 weeks’ treatment with once daily evening administration of latanoprost monotherapy (50 μg/ml) or twice daily dipivefrin monotherapy (1 mg/ml), followed by 2 weeks’ combination therapy with both drugs. RESULTS Latanoprost alone reduced IOP from 19.3 (SD 1.4) to 14.8 (0.9) mm Hg (p