Diffuse intraepithelial sebaceous carcinoma of the conjunctiva

Biopsies of several sites of limbal, bulbar, and palpebral conjunctiva (Fig 2 ) revealed a diffuse intra-epithelial malignancy with pagetoid and bowenoid growth and moderate chronic non-granulomatous inflammation in the underlying substantia propria but no evidence of stromal invasion. COMMENT The origin of the intraepithelial form of sebaceous carcinoma of the eyelid is still uncertain. 1-4 While some believe that sebaceous metaplasia of the epithelium must precede neoplastic transformation, Margo et al 1 have suggested that the tumour may arise de novo within the conjunctival epithelium since, in their case, no clear focus of neoplasia could be demonstrated in sebaceous glands of the eyelid.