Prediction of extubation failure in preterm infants
Objective: To identify whether the results of assessment of respiratory muscle strength or respiratory load were better predictors of extubation failure in preterm infants than readily available clinical data. Patients: Thirty six infants, median gestational age 31 (range 25–36) weeks and postnatal...
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| Veröffentlicht in: | Archives of disease in childhood. Fetal and neonatal edition 2002-01, Vol.86 (1), p.F32-F35 |
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| creator | Dimitriou, G Greenough, A Endo, A Cherian, S Rafferty, G F |
| description | Objective: To identify whether the results of assessment of respiratory muscle strength or respiratory load were better predictors of extubation failure in preterm infants than readily available clinical data. Patients: Thirty six infants, median gestational age 31 (range 25–36) weeks and postnatal age 3 (1–14) days; 13 were < 30 weeks of gestational age. Methods: Respiratory muscle strength was assessed by measurement of maximum inspiratory pressure generated during airway occlusion, and inspiratory load was assessed by measurement of compliance of the respiratory system. Results: Overall, seven infants failed extubation—that is, they required reintubation within 48 hours. These infants were older (p < 0.01), had a lower gestational age (p < 0.01), and generated lower maximum inspiratory pressure (p < 0.05) than the rest of the cohort. Similar results were found in the infants < 30 weeks of gestational age. Overall and in those < 30 weeks of gestational age, gestational age and postnatal age had the largest areas under the receiver operator characteristic curves. Conclusion: In very premature infants, low gestational age and older postnatal age are better predictors of extubation failure than assessment of respiratory muscle strength or respiratory load. |
| doi_str_mv | 10.1136/fn.86.1.F32 |
| format | Article |
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Patients: Thirty six infants, median gestational age 31 (range 25–36) weeks and postnatal age 3 (1–14) days; 13 were < 30 weeks of gestational age. Methods: Respiratory muscle strength was assessed by measurement of maximum inspiratory pressure generated during airway occlusion, and inspiratory load was assessed by measurement of compliance of the respiratory system. Results: Overall, seven infants failed extubation—that is, they required reintubation within 48 hours. These infants were older (p < 0.01), had a lower gestational age (p < 0.01), and generated lower maximum inspiratory pressure (p < 0.05) than the rest of the cohort. Similar results were found in the infants < 30 weeks of gestational age. Overall and in those < 30 weeks of gestational age, gestational age and postnatal age had the largest areas under the receiver operator characteristic curves. Conclusion: In very premature infants, low gestational age and older postnatal age are better predictors of extubation failure than assessment of respiratory muscle strength or respiratory load.]]></description><identifier>ISSN: 1359-2998</identifier><identifier>EISSN: 1468-2052</identifier><identifier>DOI: 10.1136/fn.86.1.F32</identifier><identifier>PMID: 11815545</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Age ; Age Factors ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Babies ; Biological and medical sciences ; Birth weight ; Caffeine ; Care and treatment ; Chest ; compliance of the respiratory system ; continuous positive airways pressure ; CPAP ; CRS ; Diseases of mother, fetus and pregnancy ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; extubation ; Fio2 ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - physiopathology ; Infant, Premature, Diseases - therapy ; Infants ; Infants (Premature) ; inspiratory pressure ; inspired oxygen concentration ; Intensive care medicine ; Intubation ; Intubation, Intratracheal ; Lung Compliance ; maximum inspiratory pressure ; Medical research ; Medical sciences ; Methods ; MIP ; Original ; peak inspiratory pressure ; PIP ; Pregnancy. Fetus. Placenta ; Premature birth ; prematurity ; Pressure transducers ; receiver operator characteristic ; respiration ; Respiratory Muscles - physiopathology ; Respiratory system ; Respiratory therapy ; Risk Factors ; ROC ; ROC Curve ; Scholarships & fellowships ; Treatment Failure ; Ventilation ; Ventilator Weaning ; Ventilators ; Weaning</subject><ispartof>Archives of disease in childhood. Fetal and neonatal edition, 2002-01, Vol.86 (1), p.F32-F35</ispartof><rights>Copyright 2002 Archives of Disease in Childhood</rights><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2002 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2002 Copyright 2002 Archives of Disease in Childhood</rights><rights>Copyright National Library of Medicine - MEDLINE Abstracts Jan 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b648t-70912cfb6353389e6b036847428d675e6f8f8b401e76877d0d25c6e3437794983</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721344/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721344/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13417210$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11815545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dimitriou, G</creatorcontrib><creatorcontrib>Greenough, A</creatorcontrib><creatorcontrib>Endo, A</creatorcontrib><creatorcontrib>Cherian, S</creatorcontrib><creatorcontrib>Rafferty, G F</creatorcontrib><title>Prediction of extubation failure in preterm infants</title><title>Archives of disease in childhood. Fetal and neonatal edition</title><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><description><![CDATA[Objective: To identify whether the results of assessment of respiratory muscle strength or respiratory load were better predictors of extubation failure in preterm infants than readily available clinical data. Patients: Thirty six infants, median gestational age 31 (range 25–36) weeks and postnatal age 3 (1–14) days; 13 were < 30 weeks of gestational age. Methods: Respiratory muscle strength was assessed by measurement of maximum inspiratory pressure generated during airway occlusion, and inspiratory load was assessed by measurement of compliance of the respiratory system. Results: Overall, seven infants failed extubation—that is, they required reintubation within 48 hours. These infants were older (p < 0.01), had a lower gestational age (p < 0.01), and generated lower maximum inspiratory pressure (p < 0.05) than the rest of the cohort. Similar results were found in the infants < 30 weeks of gestational age. Overall and in those < 30 weeks of gestational age, gestational age and postnatal age had the largest areas under the receiver operator characteristic curves. Conclusion: In very premature infants, low gestational age and older postnatal age are better predictors of extubation failure than assessment of respiratory muscle strength or respiratory load.]]></description><subject>Age</subject><subject>Age Factors</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Babies</subject><subject>Biological and medical sciences</subject><subject>Birth weight</subject><subject>Caffeine</subject><subject>Care and treatment</subject><subject>Chest</subject><subject>compliance of the respiratory system</subject><subject>continuous positive airways pressure</subject><subject>CPAP</subject><subject>CRS</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>extubation</subject><subject>Fio2</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - physiopathology</subject><subject>Infant, Premature, Diseases - therapy</subject><subject>Infants</subject><subject>Infants (Premature)</subject><subject>inspiratory pressure</subject><subject>inspired oxygen concentration</subject><subject>Intensive care medicine</subject><subject>Intubation</subject><subject>Intubation, Intratracheal</subject><subject>Lung Compliance</subject><subject>maximum inspiratory pressure</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Methods</subject><subject>MIP</subject><subject>Original</subject><subject>peak inspiratory pressure</subject><subject>PIP</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Premature birth</subject><subject>prematurity</subject><subject>Pressure transducers</subject><subject>receiver operator characteristic</subject><subject>respiration</subject><subject>Respiratory Muscles - physiopathology</subject><subject>Respiratory system</subject><subject>Respiratory therapy</subject><subject>Risk Factors</subject><subject>ROC</subject><subject>ROC Curve</subject><subject>Scholarships & fellowships</subject><subject>Treatment Failure</subject><subject>Ventilation</subject><subject>Ventilator Weaning</subject><subject>Ventilators</subject><subject>Weaning</subject><issn>1359-2998</issn><issn>1468-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kkFv1DAQhSNERUvhxB2tqOBSstixYzsXpGpFC1IFFZReLccZL14Se7ETVP49U3bVBVTQHDz2fBq9eZ6ieELJnFImXrkwV2JO56esulccUC5UWZG6uo85q5uyahq1XzzMeUUIoVLKB8U-pYrWNa8PCnaRoPN29DHMopvB9Ti15tfNGd9PCWY-zNYJRkgDps6EMT8q9pzpMzzenofF59M3l4u35fmHs3eLk_OyFVyNpSQNraxrBasZUw2IljChuOSV6oSsQTjlVMsJBSmUlB3pqtoKYJxJ2fBGscPi9abvemoH6CyEMZler5MfTPqho_H6z0rwX_QyftdUVpRxjg1ebBuk-G2CPOrBZwt9bwLEKWtJORGCCASf_QWu4pQCDqcrhj7hIA1CR_-CqFQEh8BA6uWGWpoeNDoWUZpdQgBUGAM4j88nqlKKKiYRL-_AMToYvL2LP97wNsWcE7hbOyjRN-ugXdBKaKpxHZB--ruDO3b7_wg83wImW9O7ZIL1eccxfuMl2cn0eYTr27pJX7WQTNb6_dVCN5_EBTm7-qgvd863w-q_Cn8CltXVXw</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Dimitriou, G</creator><creator>Greenough, A</creator><creator>Endo, A</creator><creator>Cherian, S</creator><creator>Rafferty, G F</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><general>National Library of Medicine - MEDLINE Abstracts</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200201</creationdate><title>Prediction of extubation failure in preterm infants</title><author>Dimitriou, G ; Greenough, A ; Endo, A ; Cherian, S ; Rafferty, G F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b648t-70912cfb6353389e6b036847428d675e6f8f8b401e76877d0d25c6e3437794983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Babies</topic><topic>Biological and medical sciences</topic><topic>Birth weight</topic><topic>Caffeine</topic><topic>Care and treatment</topic><topic>Chest</topic><topic>compliance of the respiratory system</topic><topic>continuous positive airways pressure</topic><topic>CPAP</topic><topic>CRS</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>extubation</topic><topic>Fio2</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - physiopathology</topic><topic>Infant, Premature, Diseases - therapy</topic><topic>Infants</topic><topic>Infants (Premature)</topic><topic>inspiratory pressure</topic><topic>inspired oxygen concentration</topic><topic>Intensive care medicine</topic><topic>Intubation</topic><topic>Intubation, Intratracheal</topic><topic>Lung Compliance</topic><topic>maximum inspiratory pressure</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Methods</topic><topic>MIP</topic><topic>Original</topic><topic>peak inspiratory pressure</topic><topic>PIP</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Premature birth</topic><topic>prematurity</topic><topic>Pressure transducers</topic><topic>receiver operator characteristic</topic><topic>respiration</topic><topic>Respiratory Muscles - physiopathology</topic><topic>Respiratory system</topic><topic>Respiratory therapy</topic><topic>Risk Factors</topic><topic>ROC</topic><topic>ROC Curve</topic><topic>Scholarships & fellowships</topic><topic>Treatment Failure</topic><topic>Ventilation</topic><topic>Ventilator Weaning</topic><topic>Ventilators</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dimitriou, G</creatorcontrib><creatorcontrib>Greenough, A</creatorcontrib><creatorcontrib>Endo, A</creatorcontrib><creatorcontrib>Cherian, S</creatorcontrib><creatorcontrib>Rafferty, G F</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dimitriou, G</au><au>Greenough, A</au><au>Endo, A</au><au>Cherian, S</au><au>Rafferty, G F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of extubation failure in preterm infants</atitle><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><date>2002-01</date><risdate>2002</risdate><volume>86</volume><issue>1</issue><spage>F32</spage><epage>F35</epage><pages>F32-F35</pages><issn>1359-2998</issn><eissn>1468-2052</eissn><abstract><![CDATA[Objective: To identify whether the results of assessment of respiratory muscle strength or respiratory load were better predictors of extubation failure in preterm infants than readily available clinical data. Patients: Thirty six infants, median gestational age 31 (range 25–36) weeks and postnatal age 3 (1–14) days; 13 were < 30 weeks of gestational age. Methods: Respiratory muscle strength was assessed by measurement of maximum inspiratory pressure generated during airway occlusion, and inspiratory load was assessed by measurement of compliance of the respiratory system. Results: Overall, seven infants failed extubation—that is, they required reintubation within 48 hours. These infants were older (p < 0.01), had a lower gestational age (p < 0.01), and generated lower maximum inspiratory pressure (p < 0.05) than the rest of the cohort. Similar results were found in the infants < 30 weeks of gestational age. Overall and in those < 30 weeks of gestational age, gestational age and postnatal age had the largest areas under the receiver operator characteristic curves. Conclusion: In very premature infants, low gestational age and older postnatal age are better predictors of extubation failure than assessment of respiratory muscle strength or respiratory load.]]></abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>11815545</pmid><doi>10.1136/fn.86.1.F32</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Age Factors Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Babies Biological and medical sciences Birth weight Caffeine Care and treatment Chest compliance of the respiratory system continuous positive airways pressure CPAP CRS Diseases of mother, fetus and pregnancy Emergency and intensive care: neonates and children. Prematurity. Sudden death extubation Fio2 Gestational Age Gynecology. Andrology. Obstetrics Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases - physiopathology Infant, Premature, Diseases - therapy Infants Infants (Premature) inspiratory pressure inspired oxygen concentration Intensive care medicine Intubation Intubation, Intratracheal Lung Compliance maximum inspiratory pressure Medical research Medical sciences Methods MIP Original peak inspiratory pressure PIP Pregnancy. Fetus. Placenta Premature birth prematurity Pressure transducers receiver operator characteristic respiration Respiratory Muscles - physiopathology Respiratory system Respiratory therapy Risk Factors ROC ROC Curve Scholarships & fellowships Treatment Failure Ventilation Ventilator Weaning Ventilators Weaning |
| title | Prediction of extubation failure in preterm infants |
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