Faecal elastase 1 concentration is a marker of duodenal enteropathy

Background: Measurement of faecal elastase (FE1) is used widely to screen for pancreatic exocrine insufficiency (PI). FE1 does not allow differentiation of primary from secondary PI. Aims: To investigate the relation between duodenal morphology and FE1 in children with secondary PI resulting from pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of disease in childhood 2002-01, Vol.86 (1), p.50-53
Hauptverfasser:	Schäppi, M G, Smith, V V, Cubitt, D, Milla, P J, Lindley, K J
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy Aminoacid disorders Biological and medical sciences Biomarkers - analysis Biopsy CCK Celiac disease Child Child Health Child, Preschool cholecystokinin Clinical Diagnosis Cystic fibrosis Diagnosis Diagnosis-Related Groups Duodenal Diseases - complications Duodenal Diseases - diagnosis Duodenitis - complications Duodenitis - enzymology duodenum Elastases enteropathy Enzyme-Linked Immunosorbent Assay Enzymes Errors of metabolism Exocrine Pancreatic Insufficiency - enzymology Exocrine Pancreatic Insufficiency - etiology faecal elastase FE1 Feces - enzymology Female Food Food allergies gastrointestinal Histology Humans Infant Infant, Newborn Inflammation Inflammatory bowel disease Intestinal Mucosa - enzymology Linear Models Male Medical sciences Metabolic diseases Morphology Original Pancreas Pancreatic diseases Pancreatic Elastase - analysis pancreatic exocrine insufficiency pancreozymin partial villous atrophy Patients PVA Regression (Statistics) Regression analysis Retrospective Studies Screening Tests Statistical analysis VCR villus to crypt ratio
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background: Measurement of faecal elastase (FE1) is used widely to screen for pancreatic exocrine insufficiency (PI). FE1 does not allow differentiation of primary from secondary PI. Aims: To investigate the relation between duodenal morphology and FE1 in children with secondary PI resulting from primary gastrointestinal diseases. Methods: A group of 51 children underwent small intestinal biopsy and FE1 measurement. Villus to crypt ratio (VCR) and inflammation within the lamina propria of duodenal mucosal biopsy specimens were scored and compared with FE1 values. Results: In 51 children from nine diagnostic categories, a highly significant correlation between FE1 and both duodenal morphology and inflammation was found. Conclusion: Small bowel enteropathy is associated with low FE1 concentrations, indicative of secondary exocrine pancreatic insufficiency.
ISSN:	0003-9888 1468-2044
DOI:	10.1136/adc.86.1.50