Niflumic acid and cutaneous reactions in children

In a case control study of adverse drug reactions in children, the odds ratio of developing a serious mucocutaneous event among users of niflumic acid, adjusted for concomitant use of all other drugs, was 4.9 (95% CI 1.9 to 12.8). Given the availability of safer analgesics and antipyretics, there is...

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Veröffentlicht in:	Archives of disease in childhood 2001-05, Vol.84 (5), p.430-431
Hauptverfasser:	Menniti-Ippolito, F, Sagliocca, L, Da Cas, R, Saggiomo, G, Di Nardo, R, Traversa, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids adverse drug reactions Analgesics Anti-Inflammatory Agents, Non-Steroidal - adverse effects Antibiotics Biological and medical sciences Body Composition Case-Control Studies Child Child, Preschool Complications and side effects Confidence Intervals Control Groups cutaneous reactions Drug Eruptions - etiology Drug toxicity and drugs side effects treatment Emergency medical care Female Females General and Acute Paediatrics Hospitals Humans Infant Interviews Male Males Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Narcotics Neurological disorders niflumic acid Niflumic Acid - adverse effects Nonsteroidal anti-inflammatory agents Nonsteroidal anti-inflammatory drugs Odds Ratio Parenthood Education Pediatrics pharmacoepidemiology Pharmacology. Drug treatments Prescription drugs Ratios Risk Factors Side effects Surveillance Thrombocytopenia Tonsillitis Urticaria
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Zusammenfassung:	In a case control study of adverse drug reactions in children, the odds ratio of developing a serious mucocutaneous event among users of niflumic acid, adjusted for concomitant use of all other drugs, was 4.9 (95% CI 1.9 to 12.8). Given the availability of safer analgesics and antipyretics, there is no indication, in our opinion, that requires the prescription of substances which bear an increased risk.
ISSN:	0003-9888 1468-2044
DOI:	10.1136/adc.84.5.430