Status epilepticus: pathophysiology, epidemiology, and outcomes

Inhibitory neurotransmitters such as GABA later increase at the seizure focus and redress the balance between excitation and inhibition. 6 GABA also increases in the substantia nigra pars reticulata, an area that can modulate a cortical inhibitory response in adult rats, but not in immature rats. 3 Other mechanisms of inhibitory receptor modulation, such as adenosine receptor agonism, may also contribute to seizure termination. [...]the increased incidence of CSE in childhood is probably caused by a combination of increased seizure susceptibility and decreased ability to mount an adequate inhibitory response. [...]these studies do not address the question of whether mesial temporal damage which is not epileptogenic, may cause cognitive, especially memory, impairment.