Human antibody against rat gastric parietal cells and kidney brush border

Antibodies cross-reacting with rat gastric parietal cells and the brush border of renal tubules have been demonstrated at a serum dilution of 1 in 5 in 14% of 262 human subjects. The highest incidence was found in patients with autoimmune thyroiditis (27%) or pernicious anaemia (22%); normal group A...

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Veröffentlicht in:	Clinical and experimental immunology 1971-05, Vol.8 (5), p.783-789
Hauptverfasser:	Ireton, H J, Muller, H K, McGiven, A R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Pernicious - immunology Animals Antibodies - analysis Antigens - analysis Arthritis, Rheumatoid - immunology Colitis, Ulcerative - immunology Cross Reactions Epithelium - immunology Fluorescent Antibody Technique Gastric Mucosa - immunology Guinea Pigs Humans Kidney Tubules - immunology Lupus Erythematosus, Systemic - immunology Mice Rats Scleroderma, Systemic - immunology Species Specificity Thyroiditis - immunology
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Beschreibung
Zusammenfassung:	Antibodies cross-reacting with rat gastric parietal cells and the brush border of renal tubules have been demonstrated at a serum dilution of 1 in 5 in 14% of 262 human subjects. The highest incidence was found in patients with autoimmune thyroiditis (27%) or pernicious anaemia (22%); normal group AB blood donors showed an incidence of 18%. Studies with enzymes and solvents suggested that the antigen might be a protein, perhaps masked incompletely by lipid. The antibody also reacted with guinea-pig gastric parietal cells and kidney. The inability to react with human or mouse gastric parietal cells clearly distinguishes the antibody from that found commonly in patients with pernicious anaemia.
ISSN:	0009-9104 1365-2249