A gene for autosomal dominant nonsyndromic hearing loss (DFNA12) maps to chromosome 11q22-24

We performed linkage analysis in a Belgian family with autosomal dominant midfrequency hearing loss, which has a prelingual onset and a nonprogressive course in most patients. We found LOD scores >6 with markers on chromosome 11q. Analysis of key recombinants maps this deafness gene (DFNA12) to a...

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Veröffentlicht in:	American journal of human genetics 1997-05, Vol.60 (5), p.1168-1173
Hauptverfasser:	VERHOEVEN, K, VAN CAMP, G, SOMERS, T, OFFECIERS, F. E, WILLEMS, P. J, GOVAERTS, P. J, BALEMANS, W, SCHATTEMAN, I, VERSTREKEN, M, VAN LAER, L, SMITH, R. J. H, BROWN, M. R, VAN DE HEYNING, P. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Audiometry, Pure-Tone Belgium Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 11 Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Female Genes, Dominant Genetic Markers Hearing Loss, Bilateral - diagnosis Hearing Loss, Bilateral - genetics Humans Lod Score Male Medical sciences Non tumoral diseases Otorhinolaryngology. Stomatology Pedigree
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Zusammenfassung:	We performed linkage analysis in a Belgian family with autosomal dominant midfrequency hearing loss, which has a prelingual onset and a nonprogressive course in most patients. We found LOD scores >6 with markers on chromosome 11q. Analysis of key recombinants maps this deafness gene (DFNA12) to a 36-cM interval on chromosome 11q22-24, between markers D11S4120 and D11S912. The critical regions for the recessive deafness locus DFNB2 and the dominant locus DFNA11, which were previously localized to the long arm of chromosome 11, do not overlap with the candidate interval of DFNA12.
ISSN:	0002-9297 1537-6605