THE PHARMACOLOGY OF NEW ADRENERGIC NEURONE BLOCKING AGENTS, N-P-CYCLOHEXYLBENZYLTROPINIUM DERIVATIVES

The three N-p-cyclohexylbenzyltropinium derivatives studied gave rise to lasting hypotension after transient stimulation and block of sympathetic ganglia in anaesthetized and conscious animals. The drugs inhibited the contractions of the nictitating membrane and spleen evoked by pre- or postganglionic nerve stimulation. In adrenalectomized animals the pressor effect of tetramethylammonium, the hypertensive response to carotid arterial occlusion and the effect of tyramine on the nictitating membrane were also reduced. The drugs have slight or no parasympathomimetic, parasympatholytic or curare-like side-effects. The bretylium-like action of the compounds is discussed.