Failure of terfenadine as an antipruritic agent in atopic dogs: results of a double-blinded, placebo-controlled study

Terfenadine (5 mg/kg body weight, q12h) and placebo (0.5 grain/dog q12h) were both administered orally as individual agents to 18 dogs with atopy in a double-blinded study. No dog improved. Hyperactivity, polyphagia, lethargy, anorexia, increased pruritus, or ocular discharge were seen in three dogs...

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Veröffentlicht in:	Canadian veterinary journal 1994-05, Vol.35 (5), p.286-288
Hauptverfasser:	Scott, D.W, Miller, W.H. Jr, Cayatte, S.M, Decker, G.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals ANTIHISTAMINICOS ANTIHISTAMINICS ANTIHISTAMINIQUE APPLICATION METHODS ATOPIA ATOPIE ATOPY CHIEN Dog Diseases - drug therapy DOGS Double-Blind Method DRUGS EFFICACY Female Hypersensitivity, Immediate - complications Hypersensitivity, Immediate - drug therapy Hypersensitivity, Immediate - veterinary Male MEDICAMENT MEDICAMENTOS METHODE D'APPLICATION METODOS DE APLICACION ORAL ADMINISTRATION PERRO Pruritus - drug therapy Pruritus - etiology Pruritus - veterinary Terfenadine - administration & dosage Terfenadine - adverse effects Treatment Failure
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Beschreibung
Zusammenfassung:	Terfenadine (5 mg/kg body weight, q12h) and placebo (0.5 grain/dog q12h) were both administered orally as individual agents to 18 dogs with atopy in a double-blinded study. No dog improved. Hyperactivity, polyphagia, lethargy, anorexia, increased pruritus, or ocular discharge were seen in three dogs treated with terfenadine. Under the conditions of the study, terfenadine was not a useful antipruritic agent for the atopic dog.
ISSN:	0008-5286