Complex segregation analysis of Gilles de la Tourette syndrome: further evidence for a major locus mode of transmission

A sample of 35 published pedigrees of Gilles de la Tourette syndrome is studied using complex segregation analysis with pointers. Results indicate the presence of a rare, semidominant, incompletely penetrant allele leading to affection. This result is consistent with that previously reported by Comi...

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Veröffentlicht in:	American journal of human genetics 1984-05, Vol.36 (3), p.704-709
1. Verfasser:	DEVOR, E. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological and medical sciences Chromosome Mapping Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Genes Humans Male Medical sciences Models, Genetic Neurology Pedigree Probability Tourette Syndrome - genetics
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Zusammenfassung:	A sample of 35 published pedigrees of Gilles de la Tourette syndrome is studied using complex segregation analysis with pointers. Results indicate the presence of a rare, semidominant, incompletely penetrant allele leading to affection. This result is consistent with that previously reported by Comings et al. on a larger, independent sample.
ISSN:	0002-9297 1537-6605