Effect of intrahypothalamic phentolamine on hypothermia produced by peripheral noradrenaline in the pigeon

1 The effect of intrahypothalamic phentolamine (1 and 2 μl of a 10 μg/μl solution) on hypothermia induced by intramuscular injection of noradrenaline (NA, 2 mg/kg) at different times (2, 10, 20 min) after phentolamine was investigated in pigeons. 2 Administration of phentolamine shortly before NA wa...

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Veröffentlicht in:	British journal of pharmacology 1977-10, Vol.61 (2), p.163-166
Hauptverfasser:	Hissa, R, Pyornila, A
Format:	Artikel
Sprache:	eng
Schlagworte:	animal science Animals Body Temperature - drug effects Columbidae - physiology Female Hypothalamus Injections Injections, Intramuscular livestock Male Norepinephrine - pharmacology Oxygen Consumption - drug effects Phentolamine - administration & dosage Phentolamine - pharmacology Stereotaxic Techniques zoology
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Zusammenfassung:	1 The effect of intrahypothalamic phentolamine (1 and 2 μl of a 10 μg/μl solution) on hypothermia induced by intramuscular injection of noradrenaline (NA, 2 mg/kg) at different times (2, 10, 20 min) after phentolamine was investigated in pigeons. 2 Administration of phentolamine shortly before NA was shown to attenuate hypothermic responses to NA. 3 It is suggested that the attenuation is due to blockade of central hypothermic effects of intramuscular NA. 4 The mapping of injection sites in the brains was carried out.
ISSN:	0007-1188 1476-5381
DOI:	10.1111/j.1476-5381.1977.tb08400.x