THE CHOLINERGIC COMPONENT IN THE REFLEX VASODILATATION ELICITED BY STIMULATION OF THE DEPRESSOR NERVES IN THE RABBIT

1 The effects of the stimulation of the cephalic endings of the depressor nerve on the resistance in the perfused hindlimb were studied in the rabbit. 2 The vasodilatation thus elicited in the perfused hindlimb was reduced either by administration of guanethidine or by sympathectomy and abolished by...

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Veröffentlicht in:	British journal of pharmacology 1976-07, Vol.57 (3), p.375-379
Hauptverfasser:	CHIARIELLO, M., CONDORELLI, M., CAPRIO, L., RENGO, F., SACCÀ, L., TRIMARCO, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atropine - pharmacology Blood Pressure - drug effects Electric Stimulation Guanethidine - pharmacology Hindlimb - physiology Histamine - pharmacology Male Nitrites - pharmacology Parasympathetic Nervous System - physiology Rabbits Reflex Regional Blood Flow - drug effects Sympathetic Nervous System - physiology Vasodilator Agents - pharmacology
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Beschreibung
Zusammenfassung:	1 The effects of the stimulation of the cephalic endings of the depressor nerve on the resistance in the perfused hindlimb were studied in the rabbit. 2 The vasodilatation thus elicited in the perfused hindlimb was reduced either by administration of guanethidine or by sympathectomy and abolished by subsequent treatment with atropine. 3 These data confirm the existence of two components in the genesis of the reflex vasodilatation: a passive component, due to the inhibition of sympathetic discharge, and an active component which in the rabbit is cholinergic in nature.
ISSN:	0007-1188 1476-5381
DOI:	10.1111/j.1476-5381.1976.tb07676.x