SENSITIVITY OF NEONATAL RABBIT ILEUM TO HISTAMINE

SENSITIVITY OF NEONATAL RABBIT ILEUM TO HISTAMINE

Segments of ileum from newborn rabbits contracted in response to histamine but sensitivity declined from age 11 days. Intestine from adult animals barely contracted to histamine, even in a concentration of 3 × 10−3 M. Such variation with age was not observed with acetylcholine. The response to hista...

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Veröffentlicht in:British journal of pharmacology 1975-03, Vol.53 (3), p.428-429
1. Verfasser: BOTTING, J.H.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine - pharmacology
Animals
Animals, Newborn - physiology
Female
Histamine - pharmacology
Ileum - drug effects
In Vitro Techniques
Male
Muscle Contraction - drug effects
Pyrilamine - pharmacology
Rabbits
Receptors, Drug
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Zusammenfassung:Segments of ileum from newborn rabbits contracted in response to histamine but sensitivity declined from age 11 days. Intestine from adult animals barely contracted to histamine, even in a concentration of 3 × 10−3 M. Such variation with age was not observed with acetylcholine. The response to histamine was effected by mepyramine‐sensitive receptors which appeared to decrease in number as the animals aged.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1975.tb07381.x