Interaction between Doxycycline and Barbiturates

In a cross-over study of five hospitalized patients the half life of doxycycline was significantly shortened after 10 days' treatment with phenobarbitone. In five patients on continuous barbiturate therapy the half life of doxycycline was even shorter. Barbiturates or other agents inducing drug...

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Veröffentlicht in:	BMJ 1974-03, Vol.1 (5907), p.535-536
Hauptverfasser:	Neuvonen, P. J., Penttilä, O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amobarbital - pharmacology Antibiotics Barbiturates Barbiturates - pharmacology Carbamazepine - pharmacology Clinical pharmacology Dosage Doxycycline - administration & dosage Doxycycline - blood Doxycycline - metabolism Drug Interactions Enzyme Induction Female Half lives Half-Life Humans Male Medical journals Middle Aged Papers and Originals Pentobarbital - pharmacology Phenobarbital - administration & dosage Phenobarbital - pharmacology Phenytoin - pharmacology
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Beschreibung
Zusammenfassung:	In a cross-over study of five hospitalized patients the half life of doxycycline was significantly shortened after 10 days' treatment with phenobarbitone. In five patients on continuous barbiturate therapy the half life of doxycycline was even shorter. Barbiturates or other agents inducing drug metabolism should be used cautiously in combination with doxycycline, since this might result in therapeutically inadequate serum concentrations of the antibiotic.
ISSN:	0007-1447 0959-8138 1468-5833
DOI:	10.1136/bmj.1.5907.535