Neonatal systemic candidiasis: a failure to respond to intravenous miconazole in two neonates

Two extremely preterm infants undergoing intensive care who developed systemic candidiasis are reported. Each was treated initially with intravenous miconazole. One child initially responded, but relapsed after the miconazole was stopped. The second child showed evidence of progression of the diseas...

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Veröffentlicht in:	Archives of disease in childhood 1982-11, Vol.57 (11), p.884-886
Hauptverfasser:	McDougall, P N, Fleming, P J, Speller, D C, Daish, P, Speidel, B D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - therapeutic use Candida Candidiasis - drug therapy Drug Therapy, Combination Flucytosine - therapeutic use Humans Imidazoles - therapeutic use Infant, Newborn Infant, Premature, Diseases - drug therapy Injections, Intravenous Male Miconazole - administration & dosage Miconazole - therapeutic use Short Reports
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Zusammenfassung:	Two extremely preterm infants undergoing intensive care who developed systemic candidiasis are reported. Each was treated initially with intravenous miconazole. One child initially responded, but relapsed after the miconazole was stopped. The second child showed evidence of progression of the disease during treatment. Both infants responded to a combined course of amphotericin B and 5-fluorocytosine. The authors consider that miconazole is not the drug of first choice in the treatment of neonatal systemic candidiasis.
ISSN:	0003-9888 1468-2044
DOI:	10.1136/adc.57.11.884