The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel

[...]the ability of quinidine ability to block Na+ channels is unlikely to be responsible for arrhythmias associated with acquired LQTS. [...]unlike class Ib antiarrhythmic drugs such as mexiletine and lidocaine, which preferentially block inactivated channels 51 and selectively suppress late curren...

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