The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel

[...]the ability of quinidine ability to block Na+ channels is unlikely to be responsible for arrhythmias associated with acquired LQTS. [...]unlike class Ib antiarrhythmic drugs such as mexiletine and lidocaine, which preferentially block inactivated channels 51 and selectively suppress late curren...

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Veröffentlicht in:	Journal of medical genetics 2004-05, Vol.41 (5), p.e66-e66
Hauptverfasser:	Wang, Q, Chen, S, Chen, Q, Wan, X, Shen, J, Hoeltge, G A, Timur, A A, Keating, M T, Kirsch, G E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiac arrhythmia Cell Line Cells, Cultured Deoxyribonucleic acid DNA ECG Electric Conductivity electrocardiogram Gene Frequency Genes Genetic testing Humans Long QT syndrome Long QT Syndrome - diagnosis Long QT Syndrome - genetics Long QT Syndrome - physiopathology LQTS Mutagenesis Mutation Mutation, Missense NAV1.5 Voltage-Gated Sodium Channel Online Mutation Report Patch-Clamp Techniques Patients Polymorphism, Single-Stranded Conformational Population single strand conformational analysis Sodium Channels - genetics Sodium Channels - metabolism SSCP
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Zusammenfassung:	[...]the ability of quinidine ability to block Na+ channels is unlikely to be responsible for arrhythmias associated with acquired LQTS. [...]unlike class Ib antiarrhythmic drugs such as mexiletine and lidocaine, which preferentially block inactivated channels 51 and selectively suppress late currents in LQT3 mutant channels, 30, 41, 52 quinidine would not be expected to ameliorate LQT3 defects in gating.
ISSN:	0022-2593 1468-6244 1468-6244
DOI:	10.1136/jmg.2003.013300