Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor

Oleamide (cis‐9‐octadecenoamide) exhibits some cannabimimetic responses despite its low affinities at the currently known cannabinoid receptors. Here we have investigated whether or not it is a vasorelaxant in rat small mesenteric arteries. Oleamide elicited vasorelaxation (EC50=1.2±0.2 μM, Rmax=99....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 2006-03, Vol.147 (5), p.560-568
Hauptverfasser:	Hoi, Pui Man, Hiley, C Robin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acids - pharmacology Biological and medical sciences cannabinoid receptors Capsaicin - pharmacology Dose-Response Relationship, Drug EDHF endothelium Endothelium, Vascular - physiology In Vitro Techniques Indomethacin - pharmacology Male Medical sciences Mesenteric Arteries - drug effects Mesenteric Arteries - physiology NG-Nitroarginine Methyl Ester - pharmacology Oleamide Oleic Acids - pharmacology O‐1918 Pharmacology. Drug treatments rat mesenteric artery Rats Rats, Wistar Receptors, Cannabinoid - drug effects Receptors, Cannabinoid - physiology rimonabant SR141716A TRPV Cation Channels - drug effects Vasodilator Agents - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Oleamide (cis‐9‐octadecenoamide) exhibits some cannabimimetic responses despite its low affinities at the currently known cannabinoid receptors. Here we have investigated whether or not it is a vasorelaxant in rat small mesenteric arteries. Oleamide elicited vasorelaxation (EC50=1.2±0.2 μM, Rmax=99.1±3.9%, n=8) which was reduced by endothelial removal. Nitric oxide synthase inhibition reduced the response (EC50=5.3±1.6 μM, Rmax=59.2±7.7%, n=7; P
ISSN:	0007-1188 1476-5381
DOI:	10.1038/sj.bjp.0706643