Metronidazole in prevention and treatment of bacteroides infections in elective colonic surgery

A double-blind randomised trial was carried out among 46 patients undergoing elective colonic surgery; 27 patients received prophylactic metronidazole and 19 received placebo. Anaerobic infections did not develop in any of the metronidazole-treated patients, but did develop in 11 (58%) of 19 control...

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Veröffentlicht in:	BMJ 1977-03, Vol.1 (6061), p.607-610
Hauptverfasser:	Willis, A T, Ferguson, I R, Jones, P H, Phillips, K D, Tearle, P V, Fiddian, R V, Graham, D F, Harland, D H, Hughes, D F, Knight, D, Mee, W M, Pashby, N, Rothwell-Jackson, R L, Sachdeva, A K, Sutch, I, Kilbey, C, Edwards, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaerobic bacteria Antibiotics Antimicrobials Bacterial Infections - epidemiology Bacteroides Infections - prevention & control Blood Clinical Trials as Topic Colon - surgery Gram-Negative Anaerobic Bacteria Humans Infections Male Medical specialists Metronidazole - therapeutic use Middle Aged Placebos Postoperative Complications - prevention & control Sepsis Surgeons Surgical specialties
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Beschreibung
Zusammenfassung:	A double-blind randomised trial was carried out among 46 patients undergoing elective colonic surgery; 27 patients received prophylactic metronidazole and 19 received placebo. Anaerobic infections did not develop in any of the metronidazole-treated patients, but did develop in 11 (58%) of 19 controls who were subsequently successfully treated with metronidazole.
ISSN:	0007-1447 0959-8138 1468-5833
DOI:	10.1136/bmj.1.6061.607