PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation

The production of reactive oxygen species by the NADPH oxidase complex of phagocytes plays a critical role in our defence against bacterial and fungal infections. The PX domains of two oxidase components, p47 phox and p40 phox , are known to bind phosphoinositide products of PI3Ks but the physiologi...

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Veröffentlicht in:The EMBO journal 2006-10, Vol.25 (19), p.4468-4478
Hauptverfasser: Ellson, Chris, Davidson, Keith, Anderson, Karen, Stephens, Len R, Hawkins, Phillip T
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Sprache:eng
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