Effects of Clonidine Withdrawal: Possible Mechanisms and Suggestions for Management

A severe rebound rise in blood pressure with agitation and insomnia had been noted in five patients when they had previously ceased clonidine (Catapres) This has been shown to be reproducible in these patients and to be associated with a significant increase in urinary catecholamine excretion. The b...

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Veröffentlicht in:	BMJ 1973-04, Vol.2 (5860), p.209-211
Hauptverfasser:	Hunyor, Stephen N., Hansson, Lennart, Harrison, Timothy S., Hoobler, Sibley W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergics Blood plasma Blood Pressure Catecholamines Catecholamines - blood Catecholamines - urine Clonidine - adverse effects Clonidine - therapeutic use Dosage Epinephrine - blood Epinephrine - urine Excretion Heart Rate Humans Hypertension Hypertension - drug therapy Hypertension - etiology Injections, Intravenous Norepinephrine Norepinephrine - blood Norepinephrine - urine Papers and Originals Phentolamine - administration & dosage Phentolamine - therapeutic use Propranolol - administration & dosage Propranolol - therapeutic use Sleep Initiation and Maintenance Disorders - etiology Substance Withdrawal Syndrome - drug therapy Urine
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Zusammenfassung:	A severe rebound rise in blood pressure with agitation and insomnia had been noted in five patients when they had previously ceased clonidine (Catapres) This has been shown to be reproducible in these patients and to be associated with a significant increase in urinary catecholamine excretion. The blood pressure can be controlled and the symptoms alleviated promptly by alpha and beta adrenergic receptor blockade using intravenous phentolamine and propranolol.
ISSN:	0007-1447 0959-8138 1468-5833
DOI:	10.1136/bmj.2.5860.209