Familial Occurrence of Persistent Müllerian Structures in Otherwise Normal Males

Eight cases of males with persistent Müllerian structures are reported in four pairs of unrelated siblings. A genetically inherited failure to produce or to respond to the Müllerian-inhibiting substance elaborated by the fetal testis is postulated.

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Bibliographische Detailangaben
Veröffentlicht in:	BMJ 1973-03, Vol.1 (5856), p.771-773
Hauptverfasser:	Brook, C. G. D., Wagner, H., Zachmann, M., Prader, A., Armendares, S., Frenk, S., Aleman, P., Najjar, S. S., Slim, M. S., Genton, N., Bozic, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Child Child, Preschool Cryptorchidism Cryptorchidism - pathology Disorders of Sex Development - complications Disorders of Sex Development - genetics Fallopian tubes Fallopian Tubes - abnormalities Family structure Female Genitalia, Male - abnormalities Genitalia, Male - embryology Genitalia, Male - growth & development Gonads Histology Humans Inguinal hernia Male Mullerian Ducts - abnormalities Papers and Originals Penis Siblings Testes Testicular Neoplasms - etiology Testis - pathology Uterus Uterus - abnormalities
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Beschreibung
Zusammenfassung:	Eight cases of males with persistent Müllerian structures are reported in four pairs of unrelated siblings. A genetically inherited failure to produce or to respond to the Müllerian-inhibiting substance elaborated by the fetal testis is postulated.
ISSN:	0007-1447 0959-8138 1468-5833
DOI:	10.1136/bmj.1.5856.771