Inhibition of LPS‐induced chemokine production in human lung endothelial cells by lipid conjugates anchored to the membrane

In acute respiratory distress syndrome (ARDS) induced by endotoxins, a high production of inflammatory mediators by microvascular lung endothelial cells (LMVEC) can be observed. Activation of cells by endotoxins may result in elevated secretion of phospholipase A2 (sPLA2) which is thought to contrib...

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Veröffentlicht in:	British journal of pharmacology 2002-04, Vol.135 (7), p.1665-1674
Hauptverfasser:	Beck, G Ch, Yard, B A, Schulte, J, Oberacker, R, Ackern, K van, Woude, F J van der, Krimsky, M, Kaszkin, M, Yedgar, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute respiratory distress syndrome adhesion molecules Biological and medical sciences Cell Adhesion Molecules - biosynthesis Cell Membrane - drug effects Cell Membrane - metabolism Chemokines - metabolism CXC‐chemokines Drug Interactions Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism extracellular phospholipase inhibitor Humans Hyaluronic Acid - chemistry Hyaluronic Acid - pharmacology In Vitro Techniques lipid conjugates lipopolysaccharide Lipopolysaccharides - pharmacology lipoteichonic acid Lung - cytology Medical sciences microvascular lung endothelium NF-kappa B - metabolism Phosphatidylethanolamines - chemistry Phosphatidylethanolamines - pharmacology phospholipase A2 Phospholipases A - metabolism Phospholipases A - secretion
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