Pharmacological block of the slow component of the outward delayed rectifier current (IKs) fails to lengthen rabbit ventricular muscle QTc and action potential duration

The effects of IKs block by chromanol 293B and L‐735,821 on rabbit QT‐interval, action potential duration (APD), and membrane current were compared to those of E‐4031, a recognized IKr blocker. Measurements were made in rabbit Langendorff‐perfused whole hearts, isolated papillary muscle, and single...

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Veröffentlicht in:	British journal of pharmacology 2001-01, Vol.132 (1), p.101-110
Hauptverfasser:	Lengyel, Csaba, Iost, Norbert, Virág, László, Varró, András, Lathrop, David A, Papp, Julius Gy
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiarythmic agents arrhythmia Biological and medical sciences Cardiovascular system chromanol 293B IKs, action potential duration L‐735,821 Medical sciences Pharmacology. Drug treatments rabbit heart
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Zusammenfassung:	The effects of IKs block by chromanol 293B and L‐735,821 on rabbit QT‐interval, action potential duration (APD), and membrane current were compared to those of E‐4031, a recognized IKr blocker. Measurements were made in rabbit Langendorff‐perfused whole hearts, isolated papillary muscle, and single isolated ventricular myocytes. Neither chromanol 293B (10 μM) nor L‐735,821 (100 nM) had a significant effect on QTc interval in Langendorff‐perfused hearts. E‐4031 (100 nM), on the other hand, significantly increased QTc interval (35.6±3.9%, n=8, P
ISSN:	0007-1188 1476-5381
DOI:	10.1038/sj.bjp.0703777