Effects of halothane on the transient outward K+ current in rat ventricular myocytes

Halothane has been shown to affect several membrane currents in cardiac tissue including the L‐type calcium current (ICa), sodium current and a variety of potassium currents. However, little is known about the effects of halothane on the transient outward K+ current (Ito). Single ventricular myocyte...

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Veröffentlicht in:	British journal of pharmacology 2000-09, Vol.131 (2), p.223-230
Hauptverfasser:	Davies, Lucinda A, Hopkins, Philip M, Boyett, Mark R, Harrison, Simon M
Format:	Artikel
Sprache:	eng
Schlagworte:	action potential Action Potentials - drug effects Anesthetics, Inhalation - pharmacology Animals Biological and medical sciences Calcium - metabolism Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Female halothane Halothane - pharmacology Heart Heart - drug effects Heart - physiology Heart Ventricles - drug effects In Vitro Techniques Kinetics Male Medical sciences Myocardium - metabolism Pharmacology. Drug treatments Potassium Channels - physiology potassium current Rats Toxicity: cardiovascular system Ventricular Function volatile anaesthetics
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Zusammenfassung:	Halothane has been shown to affect several membrane currents in cardiac tissue including the L‐type calcium current (ICa), sodium current and a variety of potassium currents. However, little is known about the effects of halothane on the transient outward K+ current (Ito). Single ventricular myocytes from rat hearts were voltage clamped using the whole cell patch configuration and an EGTA‐containing pipette solution to record the Ca2+‐independent, 4‐aminopyridine sensitive component of Ito. 300 μM Cd2+ or 10 μM nifedipine was used to block ICa. At +80 mV, Ito (peak current minus current at the end of the pulse) was 1.8±0.2 nA under control conditions which was reduced to 1.3±0.2 nA by 1 mM halothane (P
ISSN:	0007-1188 1476-5381
DOI:	10.1038/sj.bjp.0703565