Participation of thromboxane A2 in the cough response in guinea‐pigs: antitussive effect of ozagrel

Participation of thromboxane A2 in the cough response in guinea‐pigs: antitussive effect of ozagrel

The purpose of this study was to investigate the involvement of thromboxane A2 (TXA2) in the cough response in a guinea‐pig cough model. Here, we describe results obtained using a selective TXA2 synthetase inhibitor, ozagrel, and a selective TXA2 agonist, U‐46619. Guinea‐pigs were anaesthetized and...

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Veröffentlicht in:British journal of pharmacology 2000-09, Vol.131 (2), p.266-270
Hauptverfasser: Shinagawa, Kazuhiko, Kojima, Masami, Ichikawa, Kiyoshi, Hiratochi, Masahiro, Aoyagi, Shigemi, Akahane, Masuo
Format: Artikel
Sprache:eng
Schlagworte:
antitussive
Biological and medical sciences
Cough
Medical sciences
ozagrel
Pharmacology. Drug treatments
Respiratory system
thromboxane A2 synthetase inhibitor
U‐46619
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Zusammenfassung:The purpose of this study was to investigate the involvement of thromboxane A2 (TXA2) in the cough response in a guinea‐pig cough model. Here, we describe results obtained using a selective TXA2 synthetase inhibitor, ozagrel, and a selective TXA2 agonist, U‐46619. Guinea‐pigs were anaesthetized and exposed to an aerosol of capsaicin (100 μM) to elicit coughing. The number of coughs was 20.0±5.8 during capsaicin provocation (5 min), but only 2.8±0.4 during a 5‐min inhalation of phosphate‐buffered saline (PBS) (P
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0703553