Some Comments on Potency Measures in Mutagenicity Research

In this article, the measurement of the potency of a chemical or mixture from its dose response in a particular assay is addressed. Attention is focused on data from the Ames Salmonella assay. Three measures of potency are explored and shown to be highly correlated. The presentation then discusses s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Environmental health perspectives 1994-01, Vol.102 (suppl 1), p.91-94
Hauptverfasser:	Margolin, Barry H., Kim, Byung Soo, Melissa G. Smith, Bethel A. Fetterman, Piegorsch, Walter W., Zeiger, Errol
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenicity Chemical hazards Datasets Dosage Dose response relationship Dose-Response Relationship, Drug Environmental health Hazardous Substances - toxicity Mutagenicity Mutagenicity Tests - statistics & numerical data Rodents Salmonella Salmonella - drug effects The International Biostatistics Conference on the Study of Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In this article, the measurement of the potency of a chemical or mixture from its dose response in a particular assay is addressed. Attention is focused on data from the Ames Salmonella assay. Three measures of potency are explored and shown to be highly correlated. The presentation then discusses specific areas of research that might benefit from a study of potency.
ISSN:	0091-6765 1552-9924
DOI:	10.1289/ehp.94102s191