Effects of tumour necrosis factor‐α on left ventricular function in the rat isolated perfused heart: possible mechanisms for a decline in cardiac function

Effects of tumour necrosis factor‐α on left ventricular function in the rat isolated perfused heart: possible mechanisms for a decline in cardiac function

The cardiac depressant actions of TNF were investigated in the isolated perfused rat heart under constant flow (10 ml min−1) and constant pressure (70 mmHg) conditions, using a recirculating (50 ml) mode of perfusion. Under constant flow conditions TNF (20 ng ml−1) caused an early (

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Veröffentlicht in:British journal of pharmacology 1999-01, Vol.126 (1), p.189-196
Hauptverfasser: Edmunds, N J, Lal, H, Woodward, B
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antihypertensive Agents - pharmacology
Biological and medical sciences
Bosentan
cardiac contractility
coronary circulation
Endocannabinoids
Endothelin Receptor Antagonists
Endothelin-1 - pharmacology
Enzyme Inhibitors - pharmacology
Ethanolamines - pharmacology
Fundamental and applied biological sciences. Psychology
Heart
Heart - drug effects
Heart - physiology
Heart Rate - drug effects
Heart Ventricles - drug effects
In Vitro Techniques
Indomethacin - pharmacology
Male
Myocardial Contraction - drug effects
Nitroarginine - pharmacology
N‐oleoylethanolamine
Oleic Acids
Perfusion
Pressure
Rats
Rats, Wistar
Sphingomyelin Phosphodiesterase - pharmacology
sphingomyelinase
sphingosine
Starling curve
Stroke Volume - drug effects
Stroke Volume - physiology
Sulfonamides - pharmacology
Temperature
TNFα
Tumor Necrosis Factor-alpha - pharmacology
Ventricular Function
Ventricular Function, Left - drug effects
Vertebrates: cardiovascular system
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Zusammenfassung:The cardiac depressant actions of TNF were investigated in the isolated perfused rat heart under constant flow (10 ml min−1) and constant pressure (70 mmHg) conditions, using a recirculating (50 ml) mode of perfusion. Under constant flow conditions TNF (20 ng ml−1) caused an early (
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0702294