Multiple effects of nordihydroguaiaretic acid on ionic currents in rat isolated type I carotid body cells

2 The effects of the lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA) on the ionic currents of rat carotid body type I cells were investigated by use of whole‐cell and outside‐out patch clamp techniques. 3 NDGA (5–50 μM) produced a concentration‐dependent inhibition of whole‐cell K+ currents...

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Veröffentlicht in:	British journal of pharmacology 1997-11, Vol.122 (5), p.923-929
Hauptverfasser:	Hatton, C. J., Peers, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood vessels and receptors Ca2+ channels Calcium Channels - drug effects Carotid body Carotid Body - cytology Carotid Body - drug effects Cell Separation Cells, Cultured charybdotoxin Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Ion Channel Gating K+ channels Lipoxygenase Inhibitors - pharmacology Masoprocol - pharmacology nordihydroguaiaretic acid Patch-Clamp Techniques Potassium Channels - drug effects Pyrazoles - pharmacology Rats Rats, Wistar tetraethylammonium Vertebrates: cardiovascular system
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Zusammenfassung:	2 The effects of the lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA) on the ionic currents of rat carotid body type I cells were investigated by use of whole‐cell and outside‐out patch clamp techniques. 3 NDGA (5–50 μM) produced a concentration‐dependent inhibition of whole‐cell K+ currents at all activating test potentials (holding potential −70 mV). The time‐course of the inhibition was also concentration‐dependent and the effects of NDGA were only reversible following brief periods of exposure (
ISSN:	0007-1188 1476-5381
DOI:	10.1038/sj.bjp.0701452