Alteration of flow‐induced dilatation in mesenteric resistance arteries of L‐NAME treated rats and its partial association with induction of cyclo‐oxygenase‐2

We investigated the response to pressure (myogenic tone) and flow of rat mesenteric resistance arteries cannulated in an arteriograph which allowed the measurement of intraluminal diameter for controlled pressures and flows. Rats were treated for 3 weeks with NG‐nitro‐L‐arginine methyl ester (L‐NAME...

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Veröffentlicht in:	British journal of pharmacology 1997-05, Vol.121 (1), p.83-90
Hauptverfasser:	Henrion, Daniel, Dechaux, Elsa, Dowell, Fiona J, Maclour, Jacques, Samuel, Jane‐Lise, Lévy, Bernard I, Michel, Jean‐Baptiste
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - analogs & derivatives 6-Ketoprostaglandin F1 alpha - urine angiotensin I converting enzyme inhibitors Angiotensin-Converting Enzyme Inhibitors - administration & dosage Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Antihypertensive agents Biological and medical sciences Blood Pressure - drug effects Bradykinin - analogs & derivatives Bradykinin - pharmacology Bradykinin Receptor Antagonists Cardiovascular system Cyclooxygenase 1 Cyclooxygenase 2 cyclo‐oxygenase Drug Interactions Enzyme Induction - drug effects Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Isoenzymes - analysis Isoenzymes - biosynthesis Isoquinolines - administration & dosage Isoquinolines - pharmacology L‐NAME Male Medical sciences Membrane Proteins Mesenteric Arteries - drug effects Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Myogenic tone NG-Nitroarginine Methyl Ester - administration & dosage NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitroarginine - pharmacology Pharmacology. Drug treatments Prostaglandin-Endoperoxide Synthases - analysis Prostaglandin-Endoperoxide Synthases - biosynthesis Rats Rats, Wistar resistance arteries shear stress Tetrahydroisoquinolines Thromboxane B2 - analogs & derivatives Thromboxane B2 - urine vascular reactivity Vascular Resistance - drug effects Vasodilation - drug effects
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Zusammenfassung:	We investigated the response to pressure (myogenic tone) and flow of rat mesenteric resistance arteries cannulated in an arteriograph which allowed the measurement of intraluminal diameter for controlled pressures and flows. Rats were treated for 3 weeks with NG‐nitro‐L‐arginine methyl ester (L‐NAME, 50 mg kg−1 day−1) or L‐NAME plus the angiotensin I converting enzyme inhibitor (ACEI) quinapril (10 mg kg−1 day−1). Mean blood pressure increased significantly in chronic L‐NAME‐treated rats (155±4 mmHg, n=8, vs control 121±6 mmHg, n=10; P
ISSN:	0007-1188 1476-5381
DOI:	10.1038/sj.bjp.0701109