The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes

The antipsychotic drug haloperidol can induce a marked QT prolongation and polymorphic ventricular arrhythmias. In this study, we expressed several cloned cardiac K+ channels, including the human ether‐a‐go‐go related gene (HERG) channels, in Xenopus oocytes and tested them for their haloperidol sen...

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Veröffentlicht in:	British journal of pharmacology 1997-03, Vol.120 (5), p.968-974
Hauptverfasser:	Suessbrich, H, Schönherr, R, Heinemann, S H, Attali, B, Lang, F, Busch, A E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - pharmacology arrhythmia, torsades de pointes Biological and medical sciences Cation Transport Proteins DNA-Binding Proteins Drug toxicity and drugs side effects treatment ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels Haloperidol Haloperidol - pharmacology human ether‐a‐go‐go related gene (HERG) Humans Ion Channel Gating K+ channel Kinetics Long QT Syndrome - metabolism Medical sciences Oocytes - metabolism Pharmacology. Drug treatments Potassium Channel Blockers Potassium Channels - physiology Potassium Channels, Voltage-Gated Recombinant Proteins - antagonists & inhibitors RNA, Complementary Toxicity: cardiovascular system Trans-Activators Transcriptional Regulator ERG Xenopus
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Zusammenfassung:	The antipsychotic drug haloperidol can induce a marked QT prolongation and polymorphic ventricular arrhythmias. In this study, we expressed several cloned cardiac K+ channels, including the human ether‐a‐go‐go related gene (HERG) channels, in Xenopus oocytes and tested them for their haloperidol sensitivity. Haloperidol had only little effects on the delayed rectifier channels Kv1.1, Kv1.2, Kv1.5 and IsK, the A‐type channel Kv1.4 and the inward rectifier channel Kir2.1 (inhibition
ISSN:	0007-1188 1476-5381
DOI:	10.1038/sj.bjp.0700989