Oral iron and the bioavailability of zinc

The oral bioavailability of zinc was studied in nonpregnant adults before and 24 hours after two weeks of oral supplementation with iron and folic acid. Bioavailability was greatly reduced, and the shape of the plasma curves suggested that this was due to impairment of the intestinal absorption of z...

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Veröffentlicht in:	BMJ 1983-10, Vol.287 (6398), p.1013-1014
Hauptverfasser:	Meadows, N J, Grainger, S L, Ruse, W, Keeling, P W, Thompson, R P
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption Bioavailability Biological and medical sciences Biological Availability blood chemistry Blood plasma Clinical Research Dosage Female Folic Acid - pharmacology Fundamental and applied biological sciences. Psychology Humans Iron Iron - pharmacology Male Metabolisms and neurohumoral controls mineral metabolism nutrient uptake Pregnancy Time Factors Vertebrates: anatomy and physiology, studies on body, several organs or systems Water and mineral metabolism. Osmoregulation. Acidobasic balance Zinc Zinc - blood Zinc - pharmacology
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Beschreibung
Zusammenfassung:	The oral bioavailability of zinc was studied in nonpregnant adults before and 24 hours after two weeks of oral supplementation with iron and folic acid. Bioavailability was greatly reduced, and the shape of the plasma curves suggested that this was due to impairment of the intestinal absorption of zinc. The findings suggest that the reduced bioavailability of zinc occurs because of interelement competition in the bowel wall. This might induce zinc depletion.
ISSN:	0007-1447 0267-0623 0959-8138 1468-5833
DOI:	10.1136/bmj.287.6398.1013