Immunological investigations in individuals with selective IgA deficiency
Concentrations of IgG2, IgG4 and IgE were low in 16, 24 and 20% of 25 persons with selective IgA deficiency. Fifty-two per cent had IgD concentrations below 5 iu/ml. Trends for association between any of these parameters and the presence of clinical symptoms were not significant. All patients, excep...
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| Veröffentlicht in: | Clinical and experimental immunology 1986-06, Vol.64 (3), p.510-517 |
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| container_title | Clinical and experimental immunology |
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| creator | OUT, T. A VAN MUNSTER, P. J. J DE GRAEFF, P. A THE, T. H VOSSEN, J. M ZEGERS, B. J. M |
| description | Concentrations of IgG2, IgG4 and IgE were low in 16, 24 and 20% of 25 persons with selective IgA deficiency. Fifty-two per cent had IgD concentrations below 5 iu/ml. Trends for association between any of these parameters and the presence of clinical symptoms were not significant. All patients, except one, had normal amounts of Ig-bearing lymphocytes in the blood. IgG1 antibodies against casein were increased in titre and frequency, whereas IgG4 antibodies were normal. Similar results were found in other sera from persons with selective IgA deficiency. |
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Similar results were found in other sera from persons with selective IgA deficiency.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies, Antinuclear - analysis</subject><subject>Biological and medical sciences</subject><subject>Caseins - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dysgammaglobulinemia - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>IgA Deficiency</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulin A, Secretory - analysis</subject><subject>Immunoglobulin D - analysis</subject><subject>Immunoglobulin E - analysis</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin G - classification</subject><subject>Immunoglobulin M - analysis</subject><subject>Immunoglobulins - analysis</subject><subject>Immunopathology</subject><subject>Leukocyte Count</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Saliva - immunology</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE9LxDAQxYMo67r6EYQexFshSdO0uQjL4p_Cghc9lzSZdCNtWpu2st_eoGVRGBiG9-M95p2hNUl4GlPKxDlaY4xFLAhml-jK-49wcs7pCq0SJggXbI2Kom0n1zVdbZVsIutm8KOt5Wg758MZRtvZ6kk2Pvqy4yHy0IAa7QxRUW8jDcYqC04dr9GFCRDcLHuD3p8e33Yv8f71udht93FPBR5joTOhkhxMqgkmnBOj05QpRSRLuWFZBUImHIzBEiqjJU0MlzhnLE-oqYAmG_Tw69tPVQtagRsH2ZT9YFs5HMtO2vK_4uyhrLu5JCmjjGXB4H4xGLrPKbxbttYraBrpoJt8mWUUZ_kPePs36RSxlBf0u0WXPpRnBumU9ScsE4ELNt-Z0Xu8</recordid><startdate>19860601</startdate><enddate>19860601</enddate><creator>OUT, T. 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Immunoglobulinopathies</topic><topic>Immunoglobulin A, Secretory - analysis</topic><topic>Immunoglobulin D - analysis</topic><topic>Immunoglobulin E - analysis</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin G - classification</topic><topic>Immunoglobulin M - analysis</topic><topic>Immunoglobulins - analysis</topic><topic>Immunopathology</topic><topic>Leukocyte Count</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Saliva - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OUT, T. A</creatorcontrib><creatorcontrib>VAN MUNSTER, P. J. J</creatorcontrib><creatorcontrib>DE GRAEFF, P. A</creatorcontrib><creatorcontrib>THE, T. H</creatorcontrib><creatorcontrib>VOSSEN, J. M</creatorcontrib><creatorcontrib>ZEGERS, B. J. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunological investigations in individuals with selective IgA deficiency</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1986-06-01</date><risdate>1986</risdate><volume>64</volume><issue>3</issue><spage>510</spage><epage>517</epage><pages>510-517</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>Concentrations of IgG2, IgG4 and IgE were low in 16, 24 and 20% of 25 persons with selective IgA deficiency. Fifty-two per cent had IgD concentrations below 5 iu/ml. Trends for association between any of these parameters and the presence of clinical symptoms were not significant. All patients, except one, had normal amounts of Ig-bearing lymphocytes in the blood. IgG1 antibodies against casein were increased in titre and frequency, whereas IgG4 antibodies were normal. Similar results were found in other sera from persons with selective IgA deficiency.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>3491694</pmid><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult Antibodies, Antinuclear - analysis Biological and medical sciences Caseins - immunology Child Child, Preschool Dysgammaglobulinemia - immunology Female Humans IgA Deficiency Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunoglobulin A, Secretory - analysis Immunoglobulin D - analysis Immunoglobulin E - analysis Immunoglobulin G - analysis Immunoglobulin G - classification Immunoglobulin M - analysis Immunoglobulins - analysis Immunopathology Leukocyte Count Lymphocytes Male Medical sciences Middle Aged Saliva - immunology |
| title | Immunological investigations in individuals with selective IgA deficiency |
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