Immunological investigations in individuals with selective IgA deficiency

Concentrations of IgG2, IgG4 and IgE were low in 16, 24 and 20% of 25 persons with selective IgA deficiency. Fifty-two per cent had IgD concentrations below 5 iu/ml. Trends for association between any of these parameters and the presence of clinical symptoms were not significant. All patients, excep...

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Veröffentlicht in:	Clinical and experimental immunology 1986-06, Vol.64 (3), p.510-517
Hauptverfasser:	OUT, T. A, VAN MUNSTER, P. J. J, DE GRAEFF, P. A, THE, T. H, VOSSEN, J. M, ZEGERS, B. J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibodies, Antinuclear - analysis Biological and medical sciences Caseins - immunology Child Child, Preschool Dysgammaglobulinemia - immunology Female Humans IgA Deficiency Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunoglobulin A, Secretory - analysis Immunoglobulin D - analysis Immunoglobulin E - analysis Immunoglobulin G - analysis Immunoglobulin G - classification Immunoglobulin M - analysis Immunoglobulins - analysis Immunopathology Leukocyte Count Lymphocytes Male Medical sciences Middle Aged Saliva - immunology
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Zusammenfassung:	Concentrations of IgG2, IgG4 and IgE were low in 16, 24 and 20% of 25 persons with selective IgA deficiency. Fifty-two per cent had IgD concentrations below 5 iu/ml. Trends for association between any of these parameters and the presence of clinical symptoms were not significant. All patients, except one, had normal amounts of Ig-bearing lymphocytes in the blood. IgG1 antibodies against casein were increased in titre and frequency, whereas IgG4 antibodies were normal. Similar results were found in other sera from persons with selective IgA deficiency.
ISSN:	0009-9104 1365-2249