Alpha-chain disease with localized plasmacytoma of the intestine. Immunoperoxidase study

An ileocaecal tumour in a patient with alpha-chain disease in remission was studied immunohistochemically by a quantitive immunoperoxidase method. The tumour which was histologically shown to be a plasmacytoma consisted of 68% alpha cells and 15% lambda cells; no kappa cells were found. Away from th...

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Veröffentlicht in:	Clinical and experimental immunology 1976-07, Vol.25 (1), p.112-116
Hauptverfasser:	Skinner, J M, Manousos, O N, Economidou, J, Nicolaou, A, Merikas, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Heavy Chain Disease - complications Humans Immunoenzyme Techniques Immunoglobulin alpha-Chains Immunoglobulin Heavy Chains Intestinal Neoplasms - complications Intestinal Neoplasms - pathology Male Plasmacytoma - complications Plasmacytoma - pathology
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Zusammenfassung:	An ileocaecal tumour in a patient with alpha-chain disease in remission was studied immunohistochemically by a quantitive immunoperoxidase method. The tumour which was histologically shown to be a plasmacytoma consisted of 68% alpha cells and 15% lambda cells; no kappa cells were found. Away from the tumour the pattern of immunoglobulin-producing cells was normal. It is concluded that the abnormal cell causing alpha-chain disease remains inactive and that the patient developed a plasmacytoma from a different cell clone.
ISSN:	0009-9104 1365-2249