Discordance of Epstein-Barr Virus (EBV) specific humoral and cellular immunity in patients with malignant lymphomas: elevated antibody titres and lowered in vitro lymphocyte reactivity

The relationship between specific viral cellular and humoral immunity to the Epstein–Barr Virus (EBV) was investigated in thirty-one untreated patients with malignant lymphoma (ML) and sex- and age-matched controls. In vitro reactivity of peripheral blood lymphocytes to heatinactivated purified EBV,...

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Veröffentlicht in:	Clinical and experimental immunology 1978-12, Vol.34 (3), p.338-346
Hauptverfasser:	Ten Napel, C H, The, T H, Van Egten-Bijker, J, de Gast, G C, Halie, M R, Langenhuysen, M M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antibodies, Viral - biosynthesis Child Female Herpesvirus 4, Human - immunology Hodgkin Disease - immunology Humans Immunity, Cellular Lymphocyte Activation Lymphocytes - immunology Lymphoma - immunology Male Middle Aged Mitogens - pharmacology
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Zusammenfassung:	The relationship between specific viral cellular and humoral immunity to the Epstein–Barr Virus (EBV) was investigated in thirty-one untreated patients with malignant lymphoma (ML) and sex- and age-matched controls. In vitro reactivity of peripheral blood lymphocytes to heatinactivated purified EBV, in an optimal stimulating concentration, was measured with 3 H-thymidine uptake. In seropositive individuals EBV lymphocyte reactivity was positively related to EBV virus capsid antibody titres. In contrast, ML patients, especially those with Hodgkin's disease, showed markedly ( P
ISSN:	0009-9104 1365-2249