Huntington's disease and leucocyte adherence inhibition. (LAI)

Patients with Huntington's disease (HD) appear to possess a brain antigen not found in undiseased brain tissue. The tube leucocyte adherence inhibition (LAI) assay detects immunity to this putative antigen in individuals with Huntington's disease (82%), multiple sclerosis (48%), other neur...

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Veröffentlicht in:	Clinical and experimental immunology 1981-09, Vol.45 (3), p.583-589
Hauptverfasser:	Hardiwidjaja, S I, Morgan, A, Ellison, G W, Myers, L W, Pierce, W G, Barkley, D S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens - analysis Brain - immunology Humans Huntington Disease - immunology Leukocyte Adherence Inhibition Test Leukocytes - immunology Multiple Sclerosis - immunology Review
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Beschreibung
Zusammenfassung:	Patients with Huntington's disease (HD) appear to possess a brain antigen not found in undiseased brain tissue. The tube leucocyte adherence inhibition (LAI) assay detects immunity to this putative antigen in individuals with Huntington's disease (82%), multiple sclerosis (48%), other neurological disease (17%) and no neurological disease (16%). The antigen-like activity can be extracted from HD brain with 3 m KCl and precipitated with 65-80% saturated ammonium sulphate.
ISSN:	0009-9104 1365-2249